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Diagnosis, Prognosis, and Therapy of Transthyretin Amyloidosis

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source: Journal of the American College of Cardiology

year: 2015

authors: Gertz MA, Benson MD, Dyck PJ, Grogan M, Coelho T, Cruz M, Berk JL, Plante-Bordeneuve V, Schmidt HHJ, Merlini G

summary/abstract:

Transthyretin amyloidosis is a fatal disorder that is characterized primarily by progressive neuropathy and cardiomyopathy. It occurs in both a mutant form (with autosomal dominant inheritance) and a wild-type form (with predominant cardiac involvement). This article guides clinicians as to when the disease should be suspected, describes the appropriate diagnostic evaluation for those with known or suspected amyloidosis, and reviews the interventions currently available for affected patients.

organization: Mayo Clinic, USA; Indiana University School of Medicine, USA; Mayo Clinic, USA; Hospital de Santo Antonio, Portugal; Federal University of Rio de Janeiro of Brazil, Brazil; Boston University School of Medicine, USA; University Hospital Henri Mondor, France; Universitätsklinikum Münster, Germany; University of Pavia, Italy

DOI: 10.1016/j.jacc.2015.09.075

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