Leif Bergsagel, MD | oneAMYLOIDOSISvoice
×
Or register here
Global Search

Trusted Resources: People & Places

Healthcare providers, researchers, and advocates

Back to People / Healthcare Professionals
Leif Bergsagel, MD

Leif Bergsagel, MD

Healthcare Professional
Consultant
Division of Hematology/Oncology
Mayo Clinic
13400 E. Shea Blvd.
Scottsdale, Arizona, United States

Leif Bergsagel completed his graduation in science and MD from University of Toronto. He did Internship and Residency in Sunnybrook Medical Centre, Toronto. Dr. Bergsagel mainly treats these conditions: amyloidosis, monoclonal gammopathy of undetermined significance, multiple myeloma, and Waldenstrom macroglobulinemia.

Dr. Bergsagel has been involved in the studies on molecular pathogenesis of multiple myeloma, a tumor of mature, isotype-switched plasma cells. It is a uniformly fatal malignancy that is frequently preceded by a common (1 percent of adults), benign preclinical phase known as monoclonal gammopathy of undetermined significance (MGUS). Dr. Bergsagel’s laboratory is focused on understanding the molecular events that lead to the development of MGUS and its progression to multiple myeloma.

The research of Dr. Bergsagel and his colleagues has identified important subtypes of multiple myeloma that respond differently to treatment, are associated with different survival rates and form the basis for a risk-adapted approach to therapy.

 

 

Representative Publications:

Treatment With Bortezomib-based Therapy, Followed by Autologous Stem Cell Transplantation, Improves Outcomes in Light Chain Amyloidosis: A Retrospective Study

Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model 

Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

view profile

Related Content

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close

Community Key Collaborator

Support for this landing page is provided by an independent education grant from

Translation of this platform made possible through an independent education grant from

© 2024 rareLife solutions Inc.

To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.

Close