Diffuse Parenchymal Pulmonary Amyloidosis Associated With Multiple Myeloma: A Case Report and Systematic Review of the Literature | oneAMYLOIDOSISvoice
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Diffuse Parenchymal Pulmonary Amyloidosis Associated With Multiple Myeloma: A Case Report and Systematic Review of the Literature

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source: BMC Cancer

year: 2018

authors: Liu Y, Jin Z, Zhang H, Zhang Y, Shi M, Meng F, Sun Q, Cai H

summary/abstract:

Background:

Pulmonary is an uncommon site of extramedullary involvement in multiple myeloma (MM). Diffuse parenchymal amyloidosis as pulmonary manifestation of MM is even rarer. We report a rare case of diffuse parenchymal pulmonary amyloidosis associated with MM diagnosed by video-assisted thoracoscopic lung biopsy (VATLB).

Case presentation:

A 58-year-old woman complained of cough and shortness of breath. HRCT disclosed diffuse ground-glass opacifications with interlobular septal thickening in bilateral lungs. A lung-biopsy sample obtained by VATLB revealed Congo Red-positive amorphous eosinophilic deposits in the alveolar septa. Surgical biopsy of abdominal wall skin and subcutaneous fat was also performed, which showed the apple-green birefringence with polarized light on Congo red stain was demonstrated in dermis. The serum immunoelectrophoresis showed monoclonal lambda light chains. A bone marrow biopsy specimen comprised 11.5% plasma cells. She was therefore diagnosed with diffuse parenchymal pulmonary amyloidosis accompanied by MM. The patient was referred to the hematology department for further chemotherapy.

Conclusions:

It is important to recognize diffuse parenchymal pulmonary amyloidosis to avoid misdiagnosis.

organization: Nanjing University Medical School, China; Huainan Chaoyang Hospital, China

DOI: 10.1186/s12885-018-4565-5

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