Details
Amyloidosis = Extracellular deposition of misfolded proteins that disrupt normal organ function.
Although all amyloid looks similar under the microscope, the precursor protein determines the type, cause, and associated disease.
* High-yield types to remember:
AL (Primary) → Immunoglobulin light chains → Multiple
myeloma & plasma cell disorders
AA (Secondary) → Serum Amyloid A (SAA) → Chronic
inflammatory diseases (TB, RA, osteomyelitis)
ATTR → Transthyretin → Hereditary & Senile systemic
amyloidosis
Aß_M → ßz-Microglobulin → Long-term dialysis-
associated amyloidosis