Cell stress may play key role in triggering hATTR-PN

A type of cell damage called oxidative stress may be key to the development of disease symptoms in people who carry the most common TTR gene mutation that causes hereditary transthyretin amyloidosis with polyneuropathy (hATTR-PN), according to a study.

Researchers found that people with symptomatic disease tended to have elevated levels of biomarkers that indicate oxidative stress and inflammation. They also found that oxidative stress may help push the transthyretin (TTR) protein into the abnormal shape that contributes to the disease.