Eligibility criteria for clinical trials in AL amyloidosis result in exclusion of nearly half of real‐world patients

Immunoglobulin light chain (AL) amyloidosis is a rare and potentially

life‐threatening disorder characterized by the deposition of

misfolded, toxic immunoglobulin light chains in organs and tissues,

typically produced by a plasma cell (PC) clone.

1

The deposition of

amyloidogenic light chains disrupts tissue structure, leading to organ

dysfunction with a wide range of symptoms and clinical

manifestations