Head-to-head comparison of 11C-PiB and 18F-flutemetamol PET in transthyretin cardiac amyloidosis

Purpose

Amyloid positron emission tomography (PET) tracers are increasingly used to detect cardiac amyloidosis (CA). 11C-Pittsburgh compound B (PiB) and 1⁸F-flutemetamol (FMM) have demonstrated diagnostic utility for CA. However, to our knowledge, no direct head-to-head comparison has been performed in cardiac imaging. This study compared the myocardial uptake patterns of PiB and FMM PET in patients with biopsy-confirmed wild-type transthyretin-CA (ATTRwt-CA).