Indication and electrical performance of conventional, resynchronization, and conduction system pacing in transthyretin amyloid cardiomyopathy

Background

Conduction system disorders and arrhythmias may require pacemaker (PM) or implantable cardioverter-defibrillator implantation in transthyretin amyloid cardiomyopathy (ATTR-CM). The optimal mode of pacing in ATTR-CM remains unknown.

Objective

This study aimed to compare the electrical performance and clinical outcomes of conventional, resynchronization, and conduction system pacing (CSP) in ATTR-CM.

Methods

In this observational study, the effects of cardiac pacing were investigated in 250 consecutive patients with ATTR-CM presenting at Inselspital Bern between June 2019 and February 2023.