Deep inside the liver, billions of protein molecules are produced every day. Sometimes, due to aging or genetic factors a particular protein, transthyretin (also known as prealbumin) can behave badly, misfolding into an unusual structure that can cause trouble throughout the body.
This can lead to a range of symptoms including shortness of breath, ongoing fatigue, tingling in the hands, and swelling in the legs. Often, patients seek care for these concerns from different specialists. They might visit an orthopedist to address carpal tunnel syndrome or a cardiologist to consider heart failure.