Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt) Amyloidosis: Electronic Health Record-Based Descriptive Study

Abstract

This electronic health record-based study highlights distinct diagnostic patterns preceding a diagnosis of light chain (AL) and wild-type transthyretin (ATTRwt) amyloidosis; AL amyloidosis was more frequently preceded by renal, gastrointestinal, neurologic, and clonal plasma cell disorders, whereas ATTRwt amyloidosis was more commonly associated with cardiac manifestations and carpal tunnel syndrome.

Keywords: AL amyloidosis; EHR; early detection; electronic health records; electronic health records algorithms; red-flag diagnoses; transthyretin; wild type ATTR.

© Noel Estrada-Merly, Liliana E Pezzin, Rodney Sparapani, Anita D'Souza. Originally published in JMIR Medical Informatics (https://medinform.jmir.org).