Multiparametric scores are effective for validating the AL score and increased wall thickness (IWT) scores in AL amyloidosis, according to a study being presented at Heart Failure 2026.
The investigators analyzed 437 patients with AL amyloidosis who were referred between January 1, 2010, and August 31, 2025. Of these, 98 had transthoracic echocardiography (TTE) with the parameters (E/E’, RWT, GLS, TAPSE) to calculate an AL score. An additional 188 patients without AL amyloidosis underwent workup for transthyretin amyloid cardiomyopathy (ATTR-CM); 84 had interventricular septum thickness or PWTd ≥ 12mm, 78 had TTEs with the parameters (E/E’, RWT, GLS, TAPSE, SAB) to calculate an IWT score, and 109 had TTEs with the parameters (EF, PWTd, RWT) to calculate an ATTR-CM score.