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UPCOMING SESSIONS in ET
Wed, May 6, 2026 · 10:00 – 11:00 PM UTC
Webinar: Emerging Roles of TTR in ATTR-CM and Your Overall Health
Sarah C Paciulli
Click To Register
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Endomyocardial Biopsy Revisited: Diagnostic Value and Expanding Roles in Cardiac Amyloidosis

Source
Springer Nature Link

Abstract

Purpose of Review

Cardiac amyloidosis (CA) results from myocardial infiltration by misfolded amyloidogenic proteins and represents a heterogeneous group of diseases with distinct prognostic and therapeutic implications. While transthyretin amyloidosis (ATTR) and immunoglobulin light-chain amyloidosis (AL) account for the majority of clinically relevant cases, several rarer amyloid subtypes with cardiac involvement have been described.This review focusses on the role of EMB in CA, highlights its diagnostic andprognostic value, discusses procedural considerations, and outlines emergingperspectives, including its potential role in phenotyping amyloid clearance andassessing treatment response in the era of novel disease-modifying therapies.