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Amyloidosis is a group of protein-folding disorders characterized by the infiltration of multiple organs with amyloid deposits, primarily affecting the heart and kidneys. AL amyloidosis is the most serious form, often leading to significant cardiac involvement with a poor prognosis, while ATTR has varied presentations based on wild-type or mutated forms. Diagnosis relies on specific imaging and biopsy techniques, and treatment strategies differ significantly between AL and ATTR types, with ongoing research into potential therapies.
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