Key Information
Source
summary/abstract
Abstract
Transthyretin-related cardiac amyloidosis is a progressive disease with significant morbidity and mortality if left untreated. With both hereditary and wild-type forms, and an often insidious presentation of symptoms, the diagnosis may easily be missed. Early specialist referral is essential if red flags are present.
Key Points
- Transthyretin-related cardiac amyloidosis (ATTR-CA) is a frequently under-recognised cause of heart failure, particularly in older men.
- There are two forms of ATTR-CA: wild-type ATTR, which typically affects older people, and hereditary or variant ATTR, which is caused by a genetic mutation.
- Amyloid deposits often cause noncardiac problems years before cardiac symptoms appear. Key red flags include bilateral carpal tunnel syndrome, lumbar spinal stenosis and biceps tendon rupture.