Source
Global Cardiology Science And Practice
Abstract
Background and Purpose: Transthyretin (ATTR) amyloidosis, including wild-type (ATTRwt) and hereditary (ATTRv) forms, is a rare but increasingly recognized disease. This first report from the Middle East presents our experience diagnosing ATTRv amyloidosis at the Abdali National Amyloidosis Center
Methods: All referred patients underwent comprehensive evaluation. ATTR amyloidosis was established by a Perugini grade 2 or 3 positive pyrophosphate (PYP) scan, with exclusion of light chain monoclonality by serum and urine immunofixation and free light chain assay. Confirmed cases subsequently underwent genetic testing for TTR mutations
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