Diagnostic Performance of the Mayo ATTR-CM Score in Diverse Populations: Comparison With the AMY Score

Abstract

Background

The Mayo transthyretin amyloid cardiomyopathy (ATTR-CM) and AMY scores were developed to identify patients at risk for ATTR-CM. However, both were derived largely from White male cohorts with preserved ejection fraction (EF ≥40%) and their performance in more diverse populations is uncertain.

Objectives

The objective of the study was to validate and compare performance of the Mayo ATTR-CM and AMY scores across racially, ethnically, and sex-diverse populations, and across the EF spectrum.