ABSTRACT
Introduction
Light chain (AL) amyloidosis and transthyretin amyloid cardiomyopathy (ATTR-CM) are the most common types of cardiac amyloidosis. Despite similar manifestations, prognosis and treatments are distinct, emphasizing the importance of accurate and timely diagnosis. This retrospective cohort study assessed real-world diagnostic workups of adult patients suspected of having AL amyloidosis, wild-type ATTR-CM (ATTRwt-CM), or both (AL amyloidosis + ATTRwt-CM).
Methods
Data were extracted from a large electronic health record and integrated claims-clinical database (January 2017–June 2023). Workups within 24 months before the first recorded diagnosis were assessed in cohorts with AL amyloidosis (International Classification of Diseases, Tenth Revision code: E85.81 only), ATTRwt-CM (E85.82 only), or AL amyloidosis + ATTRwt-CM (E85.81 and E85.82).