TTR gene mutation may not be nerve damage cause in certain hATTR cases

People carrying the p.V142I mutation in the TTR gene — which is mostly associated with hereditary transthyretin amyloid cardiomyopathy (hATTR-CM) — often have polyneuropathy, or damage to multiple nerves, a U.S. study shows.

But while TTR mutations can cause both polyneuropathy and cardiomyopathy, data suggested that in most p.V142I carriers experiencing polyneuropathy, nerve damage was likely due to other causes, such as having diabetes or chronic kidney disease, drinking alcohol, or taking nerve-toxic medications.