Why Do PYP Scans Miss Heart Amyloidosis in V30M?

A PYP heart scan (also known as bone scintigraphy or a DPD scan) is a common imaging test used to detect transthyretin (ATTR) amyloidosis in the heart. While it is highly accurate for the wild-type form of the disease and many other mutations, it frequently produces false negative results in patients with the ATTRv V30M mutation (the “v” stands for variant, meaning it is the hereditary form of the disease) ^[1][2]. A false negative means the scan shows no amyloid buildup in the heart, even when amyloid is actually present. Because of this, doctors must rely on other tools like Echocardiograms or Cardiac MRIs to accurately check heart function in V30M patients ^[3][4].