Source
sciencedirect
Abstract
Background
Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy associated with adverse outcomes. Quantification of myocardial amyloid burden is essential for risk stratification. Although cardiac magnetic resonance (CMR)-derived extracellular volume (ECV) is the reference standard for non-invasive assessment, its use is limited by cost and availability. Therefore, simple and widely accessible tools to estimate amyloid burden are needed. This study aimed to evaluate whether a novel integrated echocardiographic–electrocardiographic (echo–ECG) index, based on the ratio of maximum septal thickness (MST) to QRS voltage in lead I and/or aVR, correlates with CMR-derived ECV in patients with CA.
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