Amyloid and the Heart

The most critical and fatal manifestation of systemic amyloidosis is cardiac involvement.

Symptoms from cardiac amyloidosis can often be vague leading to late diagnosis and misdiagnosis.

Cardiac Amyloidosis Survey: Patients With AL Amyloidosis and Their Caregiversexternal link, opens in a new tab

Types of systemic amyloidosis which affect the heart include:

• Wild type ATTR (ATTRwt) amyloidosis
• AL amyloidosis (second most common organ in AL amyloidosis)
• Hereditary amyloidosis below:
  • ATTRv
  • Apolipoprotein A1
• AA, very rarely seen