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summary/abstract
Systemic amyloidosis (ICD-10: E85.4) is multiorgan dysfunction syndrome from extracellular amyloid fibril deposition (AL, ATTR, AA). Features include cardiac (heart failure, restrictive cardiomyopathy), renal (proteinuria, nephrotic syndrome) and neurologic involvement. ISA 2024 and ESC 2023 HF guidelines recommend bone scintigraphy (DPD/PYP), free light chains and tissue biopsy. Daratumumab+CyBorD for AL; tafamidis and vutrisiran for ATTR.