Clinical Trials and Research

AbstractObjective To assess the clinical value of dual-time-point planar imaging and SPECT/CT tomographic imaging of 99mTc-PYP in diagnosing transthyretin cardiac…

AbstractThe pathogenic transthyretin (TTR) gene variant c.182G>T, p.Trp61Leu (Trp61Leu) was previously reported once, as variant transthyretin amyloidosis (ATTRv…

OverviewAll ATTRwt patients on tafamidis 61 mg treatment will be clinically evaluated before treatment initiation and subsequently every six months for the…

AbstractSystemic amyloid light-chain (AL) amyloidosis is characterized by the extracellular deposition of misfolded immunoglobulin light chains in tissues and is…

Overview The purpose of this study is to:Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment,…

OverviewTransthyretin cardiac amyloidosis causes debilitating heart failure in older adults. The proposed research will develop a personalized exercise training…

Differences versus placebo seen within 30 days, sustained to 30 monthsNew analyses suggest Attruby (acoramidis) may reduce the risk of outpatient worsening heart…

OverviewThe study is conducted in participants with Transthyretin Amyloid Cardiomyopathy (ATTR-CM), a heart disease that occurs in people with the disease ATTR…

Transthyretin amyloid cardiomyopathy (ATTR-CM) has emerged as a significant yet frequently overlooked etiology of heart failure, particularly within the elderly…

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an increasingly recognized yet frequently underdiagnosed cause of heart failure, particularly among older…