Transthyretin Amyloid Cardiomyopathy

Amyloidosis refers to a group of deposition diseases in which proteins with unstable structures misfold and aggregate into amyloid fibrils that deposit in different organs and tissues. ATTR-CM is a serious and underdiagnosed type of cardiac amyloidosis that is associated with heart failure. The unstable, misfolded proteins can build up in the heart and other parts of the body, causing the heart muscle to stiffen over time, eventually leading to heart failure. Hereditary or variant ATTR-CM (hATTR) is inherited from a relative and is caused by a mutation in the gene that produces the transthyretin protein.