Trusted Resources: Education
Scientific literature and patient education texts
Wild Type ATTR Amyloidosis (Senile Systemic Amyloidosis)
source: University College London
year: N/A
summary/abstract:Amyloidosis is a rare disease caused by abnormal deposition and accumulation of proteins in the tissues of the body. Amyloid deposits are primarily made up of protein fibres known as amyloid fibrils. These amyloid fibrils are formed when normally soluble body proteins aggregate (clump together) and then remain in the tissues instead of safely going away. About 30 different proteins are known to form amyloid deposits in humans.
These amyloid forming (‘amyloidogenic’) proteins are known as ‘precursor proteins.’ Amyloid deposits cause disease by gradually accumulating within organs and thereby disrupting the structure and damaging the function of the affected tissues.
Different types of amyloidosis are named according to the precursor proteins which form the amyloid fibrils. All have the initial ‘A’ denoting amyloidosis and letter(s) identifying the particular precursor protein which forms amyloid fibrils within the amyloid deposits.
In ATTR amyloidosis, a blood protein called transthyretin (TTR) is the amyloid precursor protein that forms the amyloid deposits. Wild-type ATTR amyloidosis, formerly known as senile systemic amyloidosis, is one of three distinct, different types of ATTR amyloidosis.
read moreRelated Content
-
D. Eric Steidley, MDDr. Steidley was born and raised in New ...
-
Princess Margaret Cancer CentreThe Princess Margaret Cancer Centre is o...
-
Pathophysiology and Treatment of Cardiac AmyloidosisAmyloid cardiomyopathy should be suspect...
-
Safety and Efficacy of Long-Term Diflunisal Administration in Hereditary Transthyretin (ATTR) AmyloidosisBackground: A recent 2-year randomized ...
-
Hereditary Transthyretin AmyloidosisClinical characteristics. Hereditary tr...
-
Morie A. Gertz, MDMorie A. Gertz is a graduate from Northw...
-
Washington University School of Medicine in St. LouisWashington University School of Medicine...
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.
To improve your experience on this site, we use cookies. This includes cookies essential for the basic functioning of our website, cookies for analytics purposes, and cookies enabling us to personalize site content. By clicking on 'Accept' or any content on this site, you agree that cookies can be placed. You may adjust your browser's cookie settings to suit your preferences.
More information
The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.