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INTRODUCTIONTransthyretin amyloid cardiomyopathy (ATTR-CM) is a chronic disease caused by transthyretin (TTR) tetramer destabilization and subsequent TTR amyloid…

AbstractObjectives: Proteinuria, amyloidosis, and kidney failure are the main long-term renal complications of familial Mediterranean fever (FMF). This study…

AbstractEnzyme catalysis is essential for molecular transformations. Here, we make use of amyloid, a fibrillar aggregate formed by stacking peptides with β-sheet,…

AbstractBackgroundGrowth-associated protein 43 (GAP-43) is a key protein involved in neuronal growth and synaptic plasticity. Alterations in GAP-43 levels have been…

AbstractAmyloid light-chain (AL) amyloidosis is characterized by the deposition of amyloid fibrils in various organs, although gallbladder involvement is rare. We…

AbstractClinical ConditionCardiac Amyloidosis (CA).Key QuestionsWhen should infiltrative cardiomyopathy be suspected, and what is the differential diagnosis? What…

AbstractAmyloid light-chain (AL) amyloidosis is characterized by the deposition of amyloid fibrils in various organs, although gallbladder involvement is rare. We…

AbstractBackgroundLeft atrial appendage occlusion (LAAO) is a valuable alternative therapy to anticoagulants for stroke prevention, and a representative study has…

Loneliness is a neuropsychiatric symptom that has been associated with cognitive impairment and dementia. We aimed to investigate whether depressive symptomatology…

ObjectiveIdentification of clinically meaningful subphenotypes of disease progression can enhance the understanding of disease heterogeneity and underlying…