Key Information
Source
Journal of the American College of Cardiology
Year
2016
summary/abstract
The amyloidoses are a group of protein-folding disorders in which >=1 organ is infiltrated by proteinaceous deposits known as amyloid. The deposits are derived from 1 of several amyloidogenic precursor proteins, and the prognosis of the disease is determined both by the organ(s) involved and the type of amyloid.
Amyloid involvement of the heart (cardiac amyloidosis) carries the worst prognosis of any involved organ, and light-chain (AL) amyloidosis is the most serious form of the disease. The last decade has seen considerable progress in understanding the amyloidoses. In this review, current and novel approaches to the diagnosis and treatment of cardiac amyloidosis are discussed, with particular reference to AL amyloidosis in the heart.
Abstract Source
https://www.ncbi.nlm.nih.gov/pubmed/27634125
Full Text Source
https://www.sciencedirect.com/science/article/pii/S0735109716346046?via%3Dihub
DOI
10.1016/j.jacc.2016.06.053
Pubdate
2016
Organisation
Harvard Medical School and Department of Medicine, USA; Brigham and Women's Hospital, USA