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Steroids for AL Amyloidosis

key information

source: Myeloma UK

year: 2017

summary/abstract:

Steroids are drugs which mimic certain hormones in the body that help to regulate and control the way the body develops and functions. There are several types of steroids. Those used in the treatment of AL amyloidosis are known as glucocorticoids.

 
Glucocorticoid steroids are known to be effective in killing abnormal plasma cells in the bone marrow without damaging normal bone marrow function. These steroids can also suppress the immune system, which can help to reduce pain caused by inflammation.
 
What Steroids are Available to Treat AL Amyloidosis?
Dexamethasone and prednisolone are the steroids most commonly used in treating AL amyloidosis. While they may be used on their own (as a monotherapy) steroids are most commonly used in combination with other AL amyloidosis treatments.
 
Steroid-containing treatment combinations include:
 
  • Melphalan and dexamethasone (Mel-Dex)
  • Melphalan and prednisolone (MP)
  • Cyclophosphamide, thalidomide and dexamethasone (CTD)
  • Cyclophosphamide, bortezomib (Velcade) and dexamethasone (CVD)
 
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