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In transthyretin (TTR) amyloid cardiomyopathy (ATTR-CM), high left ventricular (LV) amyloid load is associated with cardiac dysfunction, including worse global…

There are many well-known benefits of strength training, including stronger bones and muscles, improved heart health, and decreased abdominal fat.A new study…

AbstractBackground: Cardiac Amyloidosis (CA), specifically Transthyretin Amyloid Cardiomyopathy (ATTR-CM), is an under-recognized, progressive, and fatal disease.…

Many patients evaluated for two common forms of cardiac amyloidosis never received the testing recommended to confirm or rule out the diseases, a large analysis of…

AbstractIn a first-in-human trial (NI006-101), the monoclonal antibody cliramitug, targeting misfolded transthyretin, demonstrated a favorable safety profile and…

Brief SummaryThis study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a…

Trial Purpose and DescriptionThis is a Phase I/II, multi-center, open-label study designed to evaluate the safety, tolerability and efficacy of elranatamab in…

For East Asian adults with transthyretin amyloid cardiomyopathy (ATTR-CM), the approved therapy Amvuttra (vutrisiran) is a safe and effective treatment, with…

AbstractBackgroundLeft atrioventricular coupling index (LACI) has emerged as a powerful marker of cardiac remodeling across a variety of cardiac diseases, however…

The plasma protein transthyretin (TTR) transports retinol-binding protein and thyroxine1.Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cause of…